Revisiting Liver Injury associated with Dietary Supplements
In the 11 January, 2011 issue of Liver International, a review article discussed various case reports of liver related adverse reactions associated with the use of dietary supplements (1). The studies presented in this review occurred over a significant duration of time and the discussion does not address relevant changes to the ingredient profile of dietary supplements during this period or how that may impact conclusions related to the mechanism of liver injury in these patients. It is important to note that some of the ingredients in this review are no longer marketed and that even the same ingredient can have different safety concerns depending on how they are formulated, extracted, etc. which is often unique to a product and its manufacturer. We feel it is important to address some of these fundamental components as it relates to consumer safety.
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